A lot of patients still suffer because of lack of effective drugs. According to our experience, most of diseases can be treated, at least at animal level, from even a relatively small library (~ 4, 000 natural products or active compounds). Given the vast chemical space, any disease, even for cancer, should find a cue or multiple cues. High throughput screening and target-based drug design have achieved big success. Yet there are a lot of room for improvement.